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Application of Peptide-Based Prodrug Chemistry in Drug Development [[electronic resource] /] / by Arnab De
| Application of Peptide-Based Prodrug Chemistry in Drug Development [[electronic resource] /] / by Arnab De |
| Autore | De Arnab |
| Edizione | [1st ed. 2013.] |
| Pubbl/distr/stampa | New York, NY : , : Springer New York : , : Imprint : Springer, , 2013 |
| Descrizione fisica | 1 online resource (88 p.) |
| Disciplina | 615.19 |
| Collana | SpringerBriefs in Pharmaceutical Science & Drug Development |
| Soggetto topico |
Pharmaceutical technology
Pharmacology Diabetes Pharmaceutical Sciences/Technology Pharmacology/Toxicology |
| ISBN |
1-283-62464-8
9786613937094 1-4614-4875-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Macromolecular (specifically peptide-based) drugs could potentially be highly effective medicines. However they have a relatively short duration of action and variable therapeutic index. An example of such a peptide is Glucagon-like Peptide I which could potentially be used as a revolutionary drug for diabetes. This is because it stimulates insulin only when the blood glucose level is high thereby reducing the risk of hypoglycemia (a significant disadvantage of using insulin is that an insulin overdose is the single most potent cause of life-threatening hypoglycemia). However it’s short duration of action (half-life of 2 minutes in plasma) precludes its therapeutic use. In this volume, the use of novel therapeutics like GLP1 as an alternative to tradition insulin-based drugs in diabetes is described. Application of Peptide-Based Prodrug Chemistry in Drug Development elucidates the traditional concept of prodrugs as “specialized non-toxic protective groups used in a transient manner to alter or to eliminate certain limiting properties in the parent small molecule” (IUPAC definition). It goes on to provide insight into how prodrugs of peptides (with GLP1 as an example) could be appropriately used to extend the biological half life, broaden the therapeutic index of macromolecules and improve the pharmacodynamics of such drugs. Author explains the logic behind designing peptide prodrugs, synthetic procedures and bioassays to examine the conversion of the prodrug to the drug under therapeutic conditions. The prodrugs described slowly convert to the parent drug at physiological conditions of 37C and pH 7.2 driven by their inherent chemical instability without the need of any enzymatic cleavage. The diketopiperazine and diketomorpholine (DKP and DMP) strategies for prodrug conversion are demonstrated in detail with special emphasis on the chemical flexibility that it offers to develop prodrugs with variable time actions. This book will be of useful to chemists, biochemists, medicinal chemists, biologists and people in the medical profession (doctors). It may be used in undergraduate classes but will certainly help post-graduate students and advanced professionals. The author is grateful to Prof. Richard DiMarchi (Standiford H. Cox Professor of Chemistry and the Linda & Jack Gill Chair in Biomolecular Sciences at Indiana University) for valuable suggestions. The foreword for the book has been written by Prof. Jean Martinez, (Legion d'Honneur awarded by the French Republic; Professor of Chemistry and Medicinal Chemistry of the University of Montpellier, France; and Chairman of European Peptide Society, 2002-2010). Table of contents: Introduction -- Aapplication of Prodrug Chemistry to GLP-1 -- Experimental procedures -- Characterization of Prodrugs -- Conclusion. |
| Record Nr. | UNINA-9910438129903321 |
De Arnab
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| New York, NY : , : Springer New York : , : Imprint : Springer, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Targeted delivery of pesticides using biodegradable polymeric nanoparticles / / Arnab De [and three others]
| Targeted delivery of pesticides using biodegradable polymeric nanoparticles / / Arnab De [and three others] |
| Autore | De Arnab |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | New Delhi : , : Springer, , 2014 |
| Descrizione fisica | 1 online resource (xxiii, 99 pages) : illustrations (some color) |
| Disciplina |
541.2
610.28 |
| Collana | SpringerBriefs in Molecular Science |
| Soggetto topico |
Pesticides
Pesticides - Controlled release Pesticides - Biodegradation Polymers |
| ISBN | 81-322-1689-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introduction -- World-wide Pesticide Use -- Pesticide Application in India -- Food Contamination and Wastage by Insects -- Pesticide Formulations -- Trends and Limitations in Chemical-based Pest Management -- Biological Control of Insect Pests -- Management of Insect-pests Using Nanotechnology as Modern Approaches -- A Brief Overview of Nanotechnology -- Nanoparticulate Delivery Systems -- Nanoparticulate Formulations for Pesticide Applications -- Characterization and in vitro Release Techniques for Nanoparticulate Systems -- Reference. |
| Record Nr. | UNINA-9910298638903321 |
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De Arnab
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| New Delhi : , : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Ubiquitin Chains: Degradation and Beyond [[electronic resource] /] / by Arnab De
| Ubiquitin Chains: Degradation and Beyond [[electronic resource] /] / by Arnab De |
| Autore | De Arnab |
| Edizione | [1st ed. 2015.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 |
| Descrizione fisica | 1 online resource (119 p.) |
| Disciplina | 574.19245 |
| Collana | Springer Theses, Recognizing Outstanding Ph.D. Research |
| Soggetto topico |
Proteins
Cell cycle Immunology Protein Science Cell Cycle Analysis |
| ISBN | 3-319-14965-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1 Immune homeostasis: Activation and Downregulation of NF-κB -- 2 Regulation of NF-κB signaling by regulatory ubiquitination: specific pathways and A20 -- 3 The deubiquitinase activity of A20 is dispensable for its role in NF-κB signaling -- 4 Perspectives on regulatory ubiquitination. |
| Record Nr. | UNINA-9910298291003321 |
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De Arnab
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| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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